Publications

2025

• Wedler V., Stiegler L., Gandziarowski T., Walter J., Peukert W., Distel L., Hirsch A., Klein S.:
  Shell-by-Shell functionalized nanoparticles as radiosensitizers and radioprotectors in radiation therapy of cancer cells and tumor spheroids
  In: Colloids and Surfaces B: Biointerfaces 245 (2025), Article No.: 114276
  ISSN: 0927-7765
  DOI: 10.1016/j.colsurfb.2024.114276

2024

• Klein S., Kryschi M., Kryschi C.:
  Functional nanomaterials: Applications in medicine and life sciences
  De Gruyter, 2024
  ISBN: 9783110605495
  DOI: 10.1515/9783110605495

2023

• Eckenberger E., Raczka T., Neuhuber W., Distel L., Klein S.:
  Acriflavine-Functionalized Silica@Manganese Ferrite Nanostructures for Synergistic Radiation and Hypoxia Therapies
  In: ACS Applied Bio Materials 6 (2023), p. 3089-3102
  ISSN: 2576-6422
  DOI: 10.1021/acsabm.2c01021

2021

• Klein S., Distel L., Neuhuber W.:
  X-ray dose-enhancing impact of functionalized Au-Fe3O4nanoheterodimers on MCF-7 and A549 multicellular tumor spheroids
  In: ACS Applied Bio Materials (2021)
  ISSN: 2576-6422
  DOI: 10.1021/acsabm.0c01494
• Klein S., Distel L., Neuhuber W., Kryschi C.:
  Caffeic Acid, Quercetin and 5-Fluorocytidine-Functionalized Au-Fe3O4 Nanoheterodimers for X-ray-Triggered Drug Delivery in Breast Tumor Spheroids
  In: Nanomaterials 11 (2021)
  ISSN: 2079-4991
  DOI: 10.3390/nano11051167
• Klein S., Otto J., Harreiß C., Distel L., Leistner A., Neuhuber W., Spiecker E., Kryschi C.:
  Pt-Fe3O4, Pd-Fe3O4, and Au-Fe3O4Nanoheterodimers and Their Efficacy as Radiosensitizers in Cancer Therapy
  In: ACS Applied Bio Materials (2021)
  ISSN: 2576-6422
  DOI: 10.1021/acsabm.1c00803
• Stiegler L., Klein S., Kryschi C., Neuhuber W., Hirsch A.:
  Smart Shell-by-Shell Nanoparticles with Tunable Perylene Fluorescence in the Organic Interlayer
  In: Chemistry - A European Journal 27 (2021), p. 1655-1669
  ISSN: 0947-6539
  DOI: 10.1002/chem.202003232

2020

• Klein S., Luchs T., Leng A., Distel L., Neuhuber W., Hirsch A.:
  Encapsulation of hydrophobic drugs in shell-by- shell coated nanoparticles for radio—and chemotherapy—an in Vitro study
  In: Bioengineering 7 (2020), p. 1-22
  ISSN: 2306-5354
  DOI: 10.3390/bioengineering7040126

2019

• Klein S., Hubner J., Menter C., Distel L., Neuhuber W., Kryschi C.:
  A Facile One-Pot Synthesis of Water-Soluble, Patchy Fe3O4-Au Nanoparticles for Application in Radiation Therapy
  In: Applied Sciences 9 (2019)
  ISSN: 2076-3417
  DOI: 10.3390/app9010015
• Klein S., Smuda M., Harreiß C., Menter C., Distel L., Kryschi C.:
  Bifunctional Au-Fe3O4 Nanoheterodimers Acting as X-ray Protector in Healthy Cells and as X-ray Enhancer in Tumor Cells
  In: ACS Applied Materials and Interfaces (2019)
  ISSN: 1944-8244
  DOI: 10.1021/acsami.9b13877

2018

• Klein S., Harreiß C., Menter C., Hümmer J., Distel L., Meyer K., Hock R., Kryschi C.:
  NOBF4-Functionalized Au-Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation
  In: ACS Applied Materials and Interfaces 10 (2018), p. 17071-17080
  ISSN: 1944-8244
  DOI: 10.1021/acsami.8b03660
• Klein S., Kizaloglu M., Portilla Berlanga L., Park H., Rejek T., Hümmer J., Meyer K., Hock R., Distel L., Halik M., Kryschi C.:
  Enhanced In Vitro Biocompatibility and Water Dispersibility of Magnetite and Cobalt Ferrite Nanoparticles Employed as ROS Formation Enhancer in Radiation Cancer Therapy
  In: Small (2018)
  ISSN: 1613-6829
  DOI: 10.1002/smll.201704111
  URL: https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201704111
• Klein S., Stiegler L., Harreiß C., Distel L., Neuhuber W., Spiecker E., Hirsch A., Kryschi C.:
  Understanding the Role of Surface Charge in Cellular Uptake and X‑ray-Induced ROS Enhancing of Au−Fe3O4 Nanoheterodimers
  In: ACS Applied Bio Materials (2018), p. 2002-2011
  ISSN: 2576-6422
  DOI: 10.1021/acsabm.8b00511
• Klein S., Wegmann M., Distel L., Neuhuber W., Kryschi C.:
  APTES-Terminated ultrasmall and iron-doped silicon nanoparticles as X-Ray dose enhancer for radiation therapy
  In: Biochemical and Biophysical Research Communications 498 (2018), p. 855-861
  ISSN: 0006-291X
  DOI: 10.1016/j.bbrc.2018.03.070

2017

• Hasenöhrl D., Saha A., Strauss V., Wibmer L., Klein S., Guldi DM., Hirsch A.:
  Bulbous gold-carbon nanodot hybrid nanoclusters for cancer therapy
  In: Journal of Materials Chemistry B 5 (2017), p. 8591-8599
  ISSN: 2050-750X
  DOI: 10.1039/c7tb02039b

2016

• Klein S., Kizaloglu M., Dell'Acriprete ML., Neuhuber W., Distel L., Gonzales MC., Kryschi C.:
  Oxidized silicon nanoparticles and iron oxide nanoparticles for radiation therapy

2014

• Klein S., Sommer A., Distel L., Hazemann JL., Kroener W., Neuhuber W., Müller P., Proux O., Kryschi C.:
  Superparamagnetic iron oxide nanoparticles as novel x-ray enhancer for low-dose radiation therapy
  In: Journal of Physical Chemistry B 118 (2014), p. 6159-6166
  ISSN: 1520-6106
  DOI: 10.1021/jp5026224

2013

• Klein S., Dell'Arciprete ML., Wegmann M., Distel L., Neuhuber W., Gonzalez MC., Kryschi C.:
  Oxidized silicon nanoparticles for radiosensitization of cancer and tissue cells
  In: Biochemical and Biophysical Research Communications 434 (2013), p. 217-222
  ISSN: 0006-291X
  DOI: 10.1016/j.bbrc.2013.03.042

2012

• Klein S., Sommer A., Distel L., Neuhuber W., Kryschi C.:
  Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation
  In: Biochemical and Biophysical Research Communications 425 (2012), p. 393-397
  ISSN: 0006-291X
  DOI: 10.1016/j.bbrc.2012.07.108