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  1. Friedrich-Alexander-Universität
  2. Naturwissenschaftliche Fakultät
  3. Department Chemie und Pharmazie

Department of Chemistry and Pharmacy

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Publications

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Publications

2025

  • Wedler V., Stiegler L., Gandziarowski T., Walter J., Peukert W., Distel L., Hirsch A., Klein S.:
    Shell-by-Shell functionalized nanoparticles as radiosensitizers and radioprotectors in radiation therapy of cancer cells and tumor spheroids
    In: Colloids and Surfaces B: Biointerfaces 245 (2025), Article No.: 114276
    ISSN: 0927-7765
    DOI: 10.1016/j.colsurfb.2024.114276

2024

  • Klein S., Kryschi M., Kryschi C.:
    Functional nanomaterials: Applications in medicine and life sciences
    De Gruyter, 2024
    ISBN: 9783110605495
    DOI: 10.1515/9783110605495

2023

  • Eckenberger E., Raczka T., Neuhuber W., Distel L., Klein S.:
    Acriflavine-Functionalized Silica@Manganese Ferrite Nanostructures for Synergistic Radiation and Hypoxia Therapies
    In: ACS Applied Bio Materials 6 (2023), p. 3089-3102
    ISSN: 2576-6422
    DOI: 10.1021/acsabm.2c01021

2021

  • Klein S., Distel L., Neuhuber W.:
    X-ray dose-enhancing impact of functionalized Au-Fe3O4nanoheterodimers on MCF-7 and A549 multicellular tumor spheroids
    In: ACS Applied Bio Materials (2021)
    ISSN: 2576-6422
    DOI: 10.1021/acsabm.0c01494
  • Klein S., Distel L., Neuhuber W., Kryschi C.:
    Caffeic Acid, Quercetin and 5-Fluorocytidine-Functionalized Au-Fe3O4 Nanoheterodimers for X-ray-Triggered Drug Delivery in Breast Tumor Spheroids
    In: Nanomaterials 11 (2021)
    ISSN: 2079-4991
    DOI: 10.3390/nano11051167
  • Klein S., Otto J., Harreiß C., Distel L., Leistner A., Neuhuber W., Spiecker E., Kryschi C.:
    Pt-Fe3O4, Pd-Fe3O4, and Au-Fe3O4Nanoheterodimers and Their Efficacy as Radiosensitizers in Cancer Therapy
    In: ACS Applied Bio Materials (2021)
    ISSN: 2576-6422
    DOI: 10.1021/acsabm.1c00803
  • Stiegler L., Klein S., Kryschi C., Neuhuber W., Hirsch A.:
    Smart Shell-by-Shell Nanoparticles with Tunable Perylene Fluorescence in the Organic Interlayer
    In: Chemistry - A European Journal 27 (2021), p. 1655-1669
    ISSN: 0947-6539
    DOI: 10.1002/chem.202003232

2020

  • Klein S., Luchs T., Leng A., Distel L., Neuhuber W., Hirsch A.:
    Encapsulation of hydrophobic drugs in shell-by- shell coated nanoparticles for radio—and chemotherapy—an in Vitro study
    In: Bioengineering 7 (2020), p. 1-22
    ISSN: 2306-5354
    DOI: 10.3390/bioengineering7040126

2019

  • Klein S., Hubner J., Menter C., Distel L., Neuhuber W., Kryschi C.:
    A Facile One-Pot Synthesis of Water-Soluble, Patchy Fe3O4-Au Nanoparticles for Application in Radiation Therapy
    In: Applied Sciences 9 (2019)
    ISSN: 2076-3417
    DOI: 10.3390/app9010015
  • Klein S., Smuda M., Harreiß C., Menter C., Distel L., Kryschi C.:
    Bifunctional Au-Fe3O4 Nanoheterodimers Acting as X-ray Protector in Healthy Cells and as X-ray Enhancer in Tumor Cells
    In: ACS Applied Materials and Interfaces (2019)
    ISSN: 1944-8244
    DOI: 10.1021/acsami.9b13877

2018

  • Klein S., Harreiß C., Menter C., Hümmer J., Distel L., Meyer K., Hock R., Kryschi C.:
    NOBF4-Functionalized Au-Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation
    In: ACS Applied Materials and Interfaces 10 (2018), p. 17071-17080
    ISSN: 1944-8244
    DOI: 10.1021/acsami.8b03660
  • Klein S., Kizaloglu M., Portilla Berlanga L., Park H., Rejek T., Hümmer J., Meyer K., Hock R., Distel L., Halik M., Kryschi C.:
    Enhanced In Vitro Biocompatibility and Water Dispersibility of Magnetite and Cobalt Ferrite Nanoparticles Employed as ROS Formation Enhancer in Radiation Cancer Therapy
    In: Small (2018)
    ISSN: 1613-6829
    DOI: 10.1002/smll.201704111
    URL: https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201704111
  • Klein S., Stiegler L., Harreiß C., Distel L., Neuhuber W., Spiecker E., Hirsch A., Kryschi C.:
    Understanding the Role of Surface Charge in Cellular Uptake and X‑ray-Induced ROS Enhancing of Au−Fe3O4 Nanoheterodimers
    In: ACS Applied Bio Materials (2018), p. 2002-2011
    ISSN: 2576-6422
    DOI: 10.1021/acsabm.8b00511
  • Klein S., Wegmann M., Distel L., Neuhuber W., Kryschi C.:
    APTES-Terminated ultrasmall and iron-doped silicon nanoparticles as X-Ray dose enhancer for radiation therapy
    In: Biochemical and Biophysical Research Communications 498 (2018), p. 855-861
    ISSN: 0006-291X
    DOI: 10.1016/j.bbrc.2018.03.070

2017

  • Hasenöhrl D., Saha A., Strauss V., Wibmer L., Klein S., Guldi DM., Hirsch A.:
    Bulbous gold-carbon nanodot hybrid nanoclusters for cancer therapy
    In: Journal of Materials Chemistry B 5 (2017), p. 8591-8599
    ISSN: 2050-750X
    DOI: 10.1039/c7tb02039b

2016

  • Klein S., Kizaloglu M., Dell'Acriprete ML., Neuhuber W., Distel L., Gonzales MC., Kryschi C.:
    Oxidized silicon nanoparticles and iron oxide nanoparticles for radiation therapy

2014

  • Klein S., Sommer A., Distel L., Hazemann JL., Kroener W., Neuhuber W., Müller P., Proux O., Kryschi C.:
    Superparamagnetic iron oxide nanoparticles as novel x-ray enhancer for low-dose radiation therapy
    In: Journal of Physical Chemistry B 118 (2014), p. 6159-6166
    ISSN: 1520-6106
    DOI: 10.1021/jp5026224

2013

  • Klein S., Dell'Arciprete ML., Wegmann M., Distel L., Neuhuber W., Gonzalez MC., Kryschi C.:
    Oxidized silicon nanoparticles for radiosensitization of cancer and tissue cells
    In: Biochemical and Biophysical Research Communications 434 (2013), p. 217-222
    ISSN: 0006-291X
    DOI: 10.1016/j.bbrc.2013.03.042

2012

  • Klein S., Sommer A., Distel L., Neuhuber W., Kryschi C.:
    Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation
    In: Biochemical and Biophysical Research Communications 425 (2012), p. 393-397
    ISSN: 0006-291X
    DOI: 10.1016/j.bbrc.2012.07.108
Friedrich Alexander University Erlangen-Nürnberg
Department of Chemistry and Pharmacy

Nikolaus-Fiebiger-Str. 10
91058 Erlangen
Germany
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