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    1. Friedrich-Alexander-Universität
    2. Naturwissenschaftliche Fakultät
    3. Department Chemie und Pharmazie

    Department of Chemistry and Pharmacy

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    Publications

    2025

    • Wedler V., Stiegler L., Gandziarowski T., Walter J., Peukert W., Distel L., Hirsch A., Klein S.:
      Shell-by-Shell functionalized nanoparticles as radiosensitizers and radioprotectors in radiation therapy of cancer cells and tumor spheroids
      In: Colloids and Surfaces B: Biointerfaces 245 (2025), Article No.: 114276
      ISSN: 0927-7765
      DOI: 10.1016/j.colsurfb.2024.114276

    2024

    • Klein S., Kryschi M., Kryschi C.:
      Functional nanomaterials: Applications in medicine and life sciences
      De Gruyter, 2024
      ISBN: 9783110605495
      DOI: 10.1515/9783110605495

    2023

    • Eckenberger E., Raczka T., Neuhuber W., Distel L., Klein S.:
      Acriflavine-Functionalized Silica@Manganese Ferrite Nanostructures for Synergistic Radiation and Hypoxia Therapies
      In: ACS Applied Bio Materials 6 (2023), p. 3089-3102
      ISSN: 2576-6422
      DOI: 10.1021/acsabm.2c01021

    2021

    • Klein S., Distel L., Neuhuber W.:
      X-ray dose-enhancing impact of functionalized Au-Fe3O4nanoheterodimers on MCF-7 and A549 multicellular tumor spheroids
      In: ACS Applied Bio Materials (2021)
      ISSN: 2576-6422
      DOI: 10.1021/acsabm.0c01494
    • Klein S., Distel L., Neuhuber W., Kryschi C.:
      Caffeic Acid, Quercetin and 5-Fluorocytidine-Functionalized Au-Fe3O4 Nanoheterodimers for X-ray-Triggered Drug Delivery in Breast Tumor Spheroids
      In: Nanomaterials 11 (2021)
      ISSN: 2079-4991
      DOI: 10.3390/nano11051167
    • Klein S., Otto J., Harreiß C., Distel L., Leistner A., Neuhuber W., Spiecker E., Kryschi C.:
      Pt-Fe3O4, Pd-Fe3O4, and Au-Fe3O4Nanoheterodimers and Their Efficacy as Radiosensitizers in Cancer Therapy
      In: ACS Applied Bio Materials (2021)
      ISSN: 2576-6422
      DOI: 10.1021/acsabm.1c00803
    • Stiegler L., Klein S., Kryschi C., Neuhuber W., Hirsch A.:
      Smart Shell-by-Shell Nanoparticles with Tunable Perylene Fluorescence in the Organic Interlayer
      In: Chemistry - A European Journal 27 (2021), p. 1655-1669
      ISSN: 0947-6539
      DOI: 10.1002/chem.202003232

    2020

    • Klein S., Luchs T., Leng A., Distel L., Neuhuber W., Hirsch A.:
      Encapsulation of hydrophobic drugs in shell-by- shell coated nanoparticles for radio—and chemotherapy—an in Vitro study
      In: Bioengineering 7 (2020), p. 1-22
      ISSN: 2306-5354
      DOI: 10.3390/bioengineering7040126

    2019

    • Klein S., Hubner J., Menter C., Distel L., Neuhuber W., Kryschi C.:
      A Facile One-Pot Synthesis of Water-Soluble, Patchy Fe3O4-Au Nanoparticles for Application in Radiation Therapy
      In: Applied Sciences 9 (2019)
      ISSN: 2076-3417
      DOI: 10.3390/app9010015
    • Klein S., Smuda M., Harreiß C., Menter C., Distel L., Kryschi C.:
      Bifunctional Au-Fe3O4 Nanoheterodimers Acting as X-ray Protector in Healthy Cells and as X-ray Enhancer in Tumor Cells
      In: ACS Applied Materials and Interfaces (2019)
      ISSN: 1944-8244
      DOI: 10.1021/acsami.9b13877

    2018

    • Klein S., Harreiß C., Menter C., Hümmer J., Distel L., Meyer K., Hock R., Kryschi C.:
      NOBF4-Functionalized Au-Fe3O4 Nanoheterodimers for Radiation Therapy: Synergy Effect Due to Simultaneous Reactive Oxygen and Nitrogen Species Formation
      In: ACS Applied Materials and Interfaces 10 (2018), p. 17071-17080
      ISSN: 1944-8244
      DOI: 10.1021/acsami.8b03660
    • Klein S., Kizaloglu M., Portilla Berlanga L., Park H., Rejek T., Hümmer J., Meyer K., Hock R., Distel L., Halik M., Kryschi C.:
      Enhanced In Vitro Biocompatibility and Water Dispersibility of Magnetite and Cobalt Ferrite Nanoparticles Employed as ROS Formation Enhancer in Radiation Cancer Therapy
      In: Small (2018)
      ISSN: 1613-6829
      DOI: 10.1002/smll.201704111
      URL: https://onlinelibrary.wiley.com/doi/full/10.1002/smll.201704111
    • Klein S., Stiegler L., Harreiß C., Distel L., Neuhuber W., Spiecker E., Hirsch A., Kryschi C.:
      Understanding the Role of Surface Charge in Cellular Uptake and X‑ray-Induced ROS Enhancing of Au−Fe3O4 Nanoheterodimers
      In: ACS Applied Bio Materials (2018), p. 2002-2011
      ISSN: 2576-6422
      DOI: 10.1021/acsabm.8b00511
    • Klein S., Wegmann M., Distel L., Neuhuber W., Kryschi C.:
      APTES-Terminated ultrasmall and iron-doped silicon nanoparticles as X-Ray dose enhancer for radiation therapy
      In: Biochemical and Biophysical Research Communications 498 (2018), p. 855-861
      ISSN: 0006-291X
      DOI: 10.1016/j.bbrc.2018.03.070

    2017

    • Hasenöhrl D., Saha A., Strauss V., Wibmer L., Klein S., Guldi DM., Hirsch A.:
      Bulbous gold-carbon nanodot hybrid nanoclusters for cancer therapy
      In: Journal of Materials Chemistry B 5 (2017), p. 8591-8599
      ISSN: 2050-750X
      DOI: 10.1039/c7tb02039b

    2016

    • Klein S., Kizaloglu M., Dell'Acriprete ML., Neuhuber W., Distel L., Gonzales MC., Kryschi C.:
      Oxidized silicon nanoparticles and iron oxide nanoparticles for radiation therapy

    2014

    • Klein S., Sommer A., Distel L., Hazemann JL., Kroener W., Neuhuber W., Müller P., Proux O., Kryschi C.:
      Superparamagnetic iron oxide nanoparticles as novel x-ray enhancer for low-dose radiation therapy
      In: Journal of Physical Chemistry B 118 (2014), p. 6159-6166
      ISSN: 1520-6106
      DOI: 10.1021/jp5026224

    2013

    • Klein S., Dell'Arciprete ML., Wegmann M., Distel L., Neuhuber W., Gonzalez MC., Kryschi C.:
      Oxidized silicon nanoparticles for radiosensitization of cancer and tissue cells
      In: Biochemical and Biophysical Research Communications 434 (2013), p. 217-222
      ISSN: 0006-291X
      DOI: 10.1016/j.bbrc.2013.03.042

    2012

    • Klein S., Sommer A., Distel L., Neuhuber W., Kryschi C.:
      Superparamagnetic iron oxide nanoparticles as radiosensitizer via enhanced reactive oxygen species formation
      In: Biochemical and Biophysical Research Communications 425 (2012), p. 393-397
      ISSN: 0006-291X
      DOI: 10.1016/j.bbrc.2012.07.108
    Friedrich Alexander University Erlangen-Nürnberg
    Department of Chemistry and Pharmacy

    Nikolaus-Fiebiger-Str. 10
    91058 Erlangen
    Germany
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