Prof. Dr. Danijela Gregurec
Biointerfaces Lab
Prof. Dr. Danijela Gregurec
News
During the last two days the #brainstorm #kickoff #meeting took place at FAU Erlangen-Nürnberg. We are happy to start the #project activities with this event, that was filled with fruitful discussions and successfully developed a roadmap for the upcoming months. Thank you to all partners University of Rome “Tor Vergata”, CIC biomaGUNE, University of Helsinki, University of Glasgow and AKA Biotech for your contributions!
We are delighted to have Vicente Durán Toro joining our lab as a postdoc, working on development of next generation functional micromaterials for brain implantation!
We are excited to have Stephan Petkov starting with us as a postdoc to work on the exiting neuro-bio part of our lab!
We are grateful to receive funding from the Horizon-EIC-2022-PathfinderOpen-01 for the BRAINSTORM project. Biointerfaces will lead the BRAINSTROM project, where we and our partners will work on multimodal nanoinvasive neuromodulation technologies! We are looking to many exciting breakthroughs that BRAINSORM will bring.- Project website comes soon!
Congratulations to Lorenzo for having his review accepted in iScience! Read on exciting physical mechanisms that govern wireless nanomaterial – neuron interactions here
Danijela is delighted tio be invited for giving a talk at the Talk at the XX Brasil MRS conference to address innovations in nanomaterials as next generation of neural interfaces.
Biointerfaces wishes a warm welcome to Naside Tezcan, who will work on mechanical engineering tasks at the lab!
Biointerfaces welcomes Hany Gabriel, who will help with scientific organization and communication of the lab!
We are wishing a warm farewell to Elizaveta Shkredova. Thank you Liza, and all the best in your future endeavours!
We are grateful to the Hertha und Helmut Schmauser-Stiftung for the continued support of Biointerfaces lab. Thank you for awarding us with Hertha und Helmut Schmauser-Stiftung 2022 funds!
We are delighted to receive funding from the HORIZON-EIC-2021-PATHFINDERCHALLENGES-01-02 for CROSSBRAIN project to design exciting functional interfaces for brain stimulation!
We are delighted to have Sergio Moya visiting us under the Visiting Professor Programme and are looking forward to many new ideas arising at the interface of soft matter and sensory sciences! Welcome, Sergio!
Biointerfaces welcomes Leo Rossdeutscher who will investigate with us how toxins influence directly on chemo/thermosensitive TRPV1 ion channel!
We are happy to welcome Elif Kocar who joined biointerfaces lab to develop sophisticated nanoparticle-based biosensors!
Danijela is excited to contribute to the celebration of the CIC biomaGUNE 15th anniversary with the talk that covers her research from PhD at the center till the present day.
Danijela will give a talk at the 4th International Brain Stimulation Conference on anisotropic nanodiscs capable of dual neuromodulation.
Danijela, together with the Sensory Sciences Team at FAU will talk about senses and perception at G’SCHEID SCHLAU! with some interesting hands-on experiments!
We are delighted that the ‘wireless DBS’ paper lead by Dr. Hescham from Maastricht University is out in Nature Communications Congratulations to the whole multidisciplinary and multinational team!
Danijela is delighted for receiving EAM Starting grant from the Cluster of Excellence Engineering of Advanced Materials. Congratulations!
Congratulations to Danijela on being awarded by Dr. Hertha und Helmut Schmauser-Stiftung!
Prof. Arnd Pralle from University at Buffalo is visiting us to brainstorm new ideas on magnetic neuromodulation techniques. We are looking forward to this exciting visit.
Danijela Gregurec received the ETI (Emerging talents initiative) award from FAU. Congratulations!
Biointerfaces lab welcomes Lorenzo Signorelli who will join the group in June as a PhD student. Lorenzo will apply functional materials to study and modify neurobiological systems.
Biointerfaces lab welcomes Elizaveta Shkredova, a student assistant who will work with us on scientific organization and communication of the lab.
Biointerfaces lab welcomes Franziska Wasner, our new student assistant. Franziska will work on synthesis and coating of magnetic nanomaterials.
Danijela will talk about ‘Magnetic nanomaterials for wireless control of sensory neurons’ at the Interdisciplinary Center for Neuroscience (iCN) mini-symposia, Erlangen on February 1st, 2021.
Curriculum Vitae
Education and research experience |
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Present | Assistant professor in Sensory Sciences | FAU Erlangen-Nürnberg, Erlangen, Germany |
2020 | Postdoctoral research associate
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Massachusetts Institute of Technology
Cambridge, USA |
2016 | PhD in Molecular Biology and Biomedicine | CIC biomaGUNE, San Sebastian, Spain |
2010 | MSc in Applied Chemistry | University of Zagreb, Zagreb, Croatia |
2008 | BSc and Engineering in Chemistry, Materials and Ecology | University of Zagreb, Zagreb, Croatia |
Research visits |
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2014 | Visiting scientist | ZIK HIKE, Greifswald, Germany |
2014 | Marie Curie fellow | INIFTA, La Plata, Argentina |
Academic Career

Gregurec et al, Mol Syst Des Eng, 2019
After her MSc degree in applied chemistry at the University of Zagreb (Croatia), Danijela started her PhD in 2011 at the biomaterials research center biomaGUNE (Spain) with Dr. Moya. Her primary focus was on the design of biocompatible and bioresponsive inorganic interfaces that resemble extracellular matrix. She used these materials to study how chemical, physical, and mechanical properties of the materials govern interactions with cells. Some of her approaches implemented controlled release of bioactive ions from the polymeric surfaces and reliance on bio-inspired substrate coatings. These systems in turn allowed mechanistic studies of cell-surface interactions and determination of constituents promoting cell-substrate interactions.
In 2014 as Marie Curie fellow she visited Prof. Azzaroni’s lab at the INIFTA (Argentina) to apply electrochemical characterization methods in studies of biopolymer coatings used in tissue engineering. Later that year she was invited at the ZIK HIKE (Germany) to work with Prof. Delcea on determination of nanomechanical properties of titania-based implant surfaces with atomic force spectroscopy.

In 2016 she joined the Prof. Anikeeva Bioelectronics Group at MIT (USA) to follow her fascination for neurobiology. Her work was focused on applying the biomaterials engineering to study and modulate the interactions with nervous system. Her favourite piece of work is development of a magnetomechanical neuromodulation technology that allows for nongenetic control of neuronal signalling in the peripheral nervous system. This technology allows for wireless activation of mechanosensory cells leveraging the force (torque) exerted from the magnetic nanodiscs (MND), specifically targeted to the mechanosensitive ion channels
Research Focus Areas

We consider that radical innovations are more likely to be developed within diverse teams that operate by using connective thinking. We are forming a strong multidisciplinary lab from the fields of biophysics, materials science, chemistry, neuroscience, and neurosurgery that comes together at the core of biointerfaces.
Our expertise and interests span from engineering of tools and interfaces for cellular control and elucidating biophysical interfacial mechanisms, to the interrogation of cellular signalling in nervous systems.
We synthetise and functionalize inorganic materials to apply them in studies, aiming to replace or control biological functions.
Main research interests in the biointerfaces lab
Neural interfaces

We develop materials and technologies that drive exciting biological studies, with emphasis on the control of neurobiological processes. Our focus is to take advantage of externally applied magnetic fields coupled to magnetic nanomaterials to act as force, heat, or voltage transducers for wireless control of sensory cells.
Biosensors

We leverage physical properties of nanomaterials to build biosensors for detection of neurotoxic analytes in vitro and in vivo. Our aim is to design biosensing devices that are fast, miniaturized, and attractive for onsite testing. One of the main advantages of using nanoparticle based biosensing is the small size of the detector, being sensitive in terms of concentration and volume of analyte in respect to conventional sensors.
Neuronal mechanotransduction

We are curios in the basic transductory mechanisms in neurons, particularly in the field of mechanobiology. We study physical forces that govern the ion channel activity in primary neurons. Our focus are mechanosensitive ion channels, such as TRPV4 and Piezo1, endogenously expressed in the peripheral neurons and involved in the sensory perception such as touch, hearing, and pain.
Methods
Teaching
Neurotech: Physics and Chemistry of Neuromodulation Technologies
This course seeks to build a foundation of material properties as principles underlying electrical, optical, and magnetic approaches to neural stimulation. Main objective is to introduce students to the interdisciplinary fields involved in development of nanomaterials used for control of cellular signaling in neurobiological systems. Course will start with general introduction to the fundamentals of action potentials and neuronal signaling mediated by ion channels within the nervous system. We will discuss invasive and noninvasive approaches and material requirements to match the biophysical properties of the nervous tissue. Course will then introduce organic and inorganic micro- and nanomaterials for optical, electrical, and magnetic neuromodulation schemes. We will discuss their physical properties, synthetic and engineering approaches considering characteristics that influence signal quality and longevity in the tissues. We will highlight remote technologies conducted by magnetic nanomaterials. Students will be exposed to recent publications that emphasize key advances in the field and learn how various chemical, biological, and engineering concepts and advances are used in synergy to develop state‐of‐the‐art neurotech methods.
(Guest-)Lectures
- S. Moya. Biological fate studies of hybrid nanocarries for drug delivery: biodistribution, degradation and surface interactions in biological environments; Erlangen, Germany, 29. March 2022 (Guest-Lecture)
- A. Pralle. Magento-neuromodulation to decipher choice place-preference in mice – engineering details behind the technique; Erlangen, Germany, 05. August 2021 (Guest-Lecture)
Peer-reviewed publications
- P. Canepa, D. Gregurec, N. Liessi, S.M.C. Rotondi, S.E. Moya, E. Millo, M. Canepa, O. Cavalleri. Biofunctionalization of Porous Titanium Oxide through Amino Acid Coupling for Biomaterial Design. Materials 2023, 16, 784.
- L. Signorelli, SA. Hescham, A. Pralle, D. Gregurec; Magnetic nanomaterials for wireless thermal and mechanical neuromodulation, iScience 2022, 25, 11, 105401.
- SA. Hescham, PH. Chiang, D. Gregurec, J. Moon, MG. Christiansen, A. Jahanshahi, H. Liu, A. Pralle, P. Anikeeva, Y. Temel; Magnetothermal nanoparticle technology alleviates parkinsonian-like symptoms in mice, Nature Communication 2021, 12.
- J. Moon, M. Christiansen, S. Rao, C. Markus, D. Bono, D. Rosenfeld, D. Gregurec, G. Varnavides, P. Chiang, S. Park, P Anikeeva; Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling, Advanced Functional Materials, 2020, 2000577.
- D. Gregurec, A. W. Senko, A. Chuvilin, A. Sankararaman, P. D. Reddy, D. Rosenfeld, P. Chiang, F. Garcia, I. Tafel, G. Varnavides, E. Ciocan, P. Anikeeva; Magnetic Vortex Nanodiscs Enable Remote Magnetomechanical Neural Stimulation, ACS Nano 2020, 14.
- L M.R. Rivera, J.G. Machado, M.C. Mathpal, N.L. Chaves, D. Gregurec, S.N. Báo, L.G. Paterno, S.E. Moya, R.B. Azevedo, M.A.G. Soler, Functional glucosamine-iron oxide nanocarriers, Journal of Materials Research, 2020, 35.
- D. Rosenfeld, A.W. Senko, J. Moon, I. Yick, G. Varnavides, D. Gregurec, F. Koehler, P. Chiang, M.G. Christiansen, L. Maeng, A.S. Widge, P. Anikeeva; Transgene-free remote magnetothermal regulation of adrenal hormones, Science Advances 2020, 6.
- L.M.R. Rivera, L.G. Paterno, N.L. Chaves, D. Gregurec, S.N Bao, S.E. Moya, M. Jain, R.B. Azevedo, P.C. Morais, M.A.G. Soler; Biocompatible superparamagnetic carriers of chondroitin sulfate, CARBPOL, 2019, 6.
- D. Gregurec, N. Politakos, L., Yate, M., S.E. Moya; Strontium confinement in polyacrylic acid brushes: A soft nanoarchitectonics approach for the design of titania coatings with enhanced osseointegration, Molecular Systems Design & Engineering 2019, 4.
- X. Song, W. Tang, D. Gregurec, L. Yate, S.E. Moya, G. Wang; Layered Titanates with Fibrous Nanotopographic Features as Reservoir for Bioactive Ions to Enhance Osteogenesis, Applied Surface Science 2018, 436.
- N.E. Muzzio, M.A. Pasquale, E. Diamanti, D. Gregurec, M. Martinez Moro, O. Azzaroni, S.E. Moya; Enhanced antiadhesive properties of chitosan/hyaluronic acid polyelectrolyte multilayers driven by thermal annealing: low adherence for mammalian cells and selective decrease in adhesion for Gram-positive bacteria, Materials science and engineering 2017, 80.
- N. Muzzio, D. Gregurec, E. Diamanti, J. Irigoyen, M. Pasquale, O. Azzaroni, S.E. Moya; Thermal Annealing of Polyelectrolyte Multilayers: a New Approach for the Enhancement of Cell Adhesion, Advanced Materials Interfaces 2016, 4.
- E. Diamanti, P. Andreozzi, R. Anguiano, L. Yate, D. Gregurec, N. Politakos, R.F. Ziolo, E. Donath, S.E. Moya; The Role of Top-Layer Chemistry on the Formation of Supported Lipid Bilayers on Polyelectrolyte Multilayers: Primary versus Quaternary Amines, Physical Chemistry Chemical Physics 2016, 18.
- X. Liu, D. Gregurec, J. Irigoyen, S. Moya, R. Ciganda, C. Wang, M. Echeverria, P. Hermange, J. Ruiz, D. Astruc, Precise Localization of Cu, Ag and Au Nanoparticles in Dendrimer Nanosnakes or Inner Periphery and Consequences in Catalysis, Nature Communications, 2016, 7.
- D. Gregurec, S.E. Moya, L. Vazquez, F. Lopez Gallego; Force spectroscopy predicts thermal stability of immobilized proteins by measuring microbead mechanics, Soft matter 2016, 12.
- R. Ciganda, J. Irigoyen, D. Gregurec, R. Hernandez, S. Moya, C. Wang, J. Ruiz, D. Astruc; Liquid- Liquid Interfacial Electron Transfer from Ferrocene to Au(III): An Ultra-Simple and Fast Au Nanoparticle Synthesis in Water Under Ambient Condition, Inorganic Chemistry 2016, 55.
- E. Diamanti, D. Gregurec, M.J. Rodríguez-Presa, C. Gervasi, O. Azzaroni, S.E. Moya, High Resistivity Lipid Bilayers Assembled on Polyelectrolyte Multilayer Cushions: An Impedance Study, Langmuir 2016, 32.
- D. Eleftheria, N. Muzzio, D. Gregurec, J. Irigoyen, M. Pasquale, O. Azzaroni, S.E. Moya; Impact of thermal annealing on wettability and antifouling characteristics of alginate poly-L-lysine polyelectrolyte multilayer films, Colloids and Surfaces B: Biointerfaces 2016, 145.
- D. Gregurec, G. Wang, R. H. Pires, M. Kosutic, T. Luedtke, M. Delcea, S. Moya; Bio inspired titanium coatings: Self-assembly of collagen- alginate films for enhanced osseointegration, Journal of Materials Chemistry B 2016, 4.
- C. Wang, Ciganda, L.l. Salmon, D. Gregurec, J. Iriroyen, S.E. Moya, J. Ruiz, D. Astruc; Highly efficient transition metal nanoparticle catalysts in aqueous solutions, Angewandte Chemie International Edition 2016, 55.
- N. Muzzio, M. Pasquale, D. Gregurec, D. Eleftheria, M. Kosutic, O. Azzaroni, Sergio Moya; Polyelectrolytes Multilayers to Modulate Cell Adhesion: A Study of the Influence of Film Composition and Polyelectrolyte Interdigitation on the Adhesion of the A549 Cell Line, Macromolecular Bioscience 2015, 16.
- H. Gu, R. Ciganda, P. Castel, A. Vax, D. Gregurec, J. Irigoyen, S.E. Moya, L. Salmon, P. Zhao, J. Ruiz, Hernandez, D. Astruc; Redox-Robust Pentamethylferrocene Polymers and Supramolecular Polymers, and Controlled Self-Assembly of Pentamethylferricenium Polymer-Embedded Ag, AgI, and Au Nanoparticles, Chemistry-A European Journal 2015, 21.
- W.A. Marmisollé, D. Gregurec, S.E. Moya, O. Azzaroni; Pendant amino polyanilines as tunable electrochemically active polymers at neutral pH, Chemelectrochem 2015, 2.
- M. Levin, E. Rojas, E. Vanhala, M. Vippola, B. Liguor, K.I. Kling, I.K. Koponen, K. Mølhave, T. Tuomi, D. Gregurec, S.E. Moya, K.A. Jensen; Influence of Relative Humidity and Physical Load During Storage on Dustiness of Inorganic Nanomaterials- Implications for Testing and Risk Assessment, Journal of Nanoparticle Research 2015, 17.
- E. Diamanti, L. Cuellar, D. Gregurec, S. E. Moya, E. Donath; Role of Hydrogen Bonding and Polyanion Composition in the Formation of Lipid Bilayers on Top of Polyelectrolyte Multilayers, Langmuir 2015, 31.
- E. Diamanti, D. Gregurec, G. Romero, L. Cuellar, E. Donath, S.E. Moya; Lipid Layers on Polyelectrolyte Multilayers: Understanding Lipid – Polyelectrolyte Interactions and Applications on the Surface Engineering of Nanomaterials, Journal of Nanoscience and Nanotechnology 2016, 16.
- W.A Marmisollé, J. Irigoyen, D. Gregurec, S.E. Moya, O. Azzaroni; Bioinspired supramolecular surface chemistry: Substrate-independent, phosphate-driven growth of polyamine-based multifunctional thin films; Advanced Functional Materials, 2015, 25.
- G. Wang, S.E. Moya, Z. Lu, D. Gregurec, H. Zreiqat; Enhancing orthopedic implant bioactivity: refining the nanotopography; Nanomedicine (London), 2015, 10.
- Y. Qiu, E. Rojas, R. A. Murray, J. Irigoyen, D. Gregurec, P. Castro-Hartman, J. Fleddermann, I. Estrela- Lopis, E. Donath, S.E. Moya; Cell Uptake, Intracellular Distribution, Fate and Reactive Oxygen Species Generation of Polymer Brush Engineered CeO2-x NPs; Nanoscale, 2015, 7.
- L. Yate, L.E. Coy, D. Gregurec, W. Aperador, S.E. Moya, G. Wang; Nb-C nanocomposite films with enhanced biocompatibility and mechanical properties for hard-tissue implant applications; ACS Applied Materials & Interfaces, 2015, 7.
- D. Gregurec, N. Politakos, L. Yate, L. Dahne, S.E. Moya; Stability of polyelectrolyte multilayers in oxidizing media: a critical issue for the development of multilayer based membranes for nanofiltration; Colloid and Polymer Science, 2015, 293.
- L. Zhu, D. Gregurec, I. Reviakine; Nanoscale Departures: Excess Lipid Leaving the Surface during Supported Lipid Bilayer Formation; Langmuir, 2013, 29.
Members of biointerfaces lab
Communication and Management
Nadine I. Goldenstein
Science Communication and Management
Postdoctoral Researchers
PhD students
Student assistants
Join biointerfaces lab
We are always looking for talented individuals to join our team.
FAU students:
Student assistant for IT-Services (m/w/d)
- Tasks are:
Setup, maintenance and service of IT infrastructure (hard- and software)
Support for the maintenance of the websites
- Qualifications:
Studies in IT or related fields of study
Knowledge of statistical software and evaluation
Very good handling of MS-Office
Good knowledge of WordPress
Basic knowledge of chemistry advantageous but not mandatory
Very good knowledge of German and English
Organizational talent, ability to work in a team, and initiative
Enrollment at FAU
- Please apply only by e-mail with cover letter, resume and references in a single PDF document.
Position specifications:
The position is temporary.
It is a part-time position, 3 h/week; working hours: by agreement.
preferred duration of filling the position: 6 months.
Expected date of recruitment: 01.06.2023.
Application deadline is: 20.04.2023.
For further information please contact:
- Goldenstein, Nadine
Department Chemie und Pharmazie
Juniorprofessur für Sensory Sciences (am Chair for Aroma und Smell Research)
Telefon +49 9131 85-22840, E-Mail: nadine.goldenstein@fau.de
Please send your application to:
- Prof. Dr. Gregurec, Danijela
Department Chemie und Pharmazie
Juniorprofessur für Sensory Sciences (am Chair for Aroma und Smell Research)
Henkestrasse 91
91052 Erlangen
Student assistant for Science Management (m/w/d)
- Tasks are:
• Support in administrative tasks
• Maintenance and enhancement of databases
• Maintenance of websites
• General office work
- Qualifications:
• very good knowledge of German and English
• adept handling of MS-Office
• organizational talent, ability to work in a team and own initiative
• enrollment at FAU
• interest in science management
- Please apply only by e-mail with cover letter, resume and references in a single PDF document.
Position specifications:
The position is temporary.
It is a part-time position, 6-9 h/week; working hours: by agreement.
preferred duration of filling the position: 6 months.
Expected date of recruitment: 01.06.2023.
Application deadline is: 20.04.2023.
For further information please contact:
- Goldenstein, Nadine
Department Chemie und Pharmazie
Juniorprofessur für Sensory Sciences (am Chair for Aroma und Smell Research)
Telefon +49 9131 85-22840, E-Mail: nadine.goldenstein@fau.de
Please send your application to:
- Prof. Dr. Gregurec, Danijela
Department Chemie und Pharmazie
Juniorprofessur für Sensory Sciences (am Chair for Aroma und Smell Research)
Henkestrasse 91
91052 Erlangen
Don’t hesitate to reach out to inquire about participation as student assistant (HiWi) as well as possibilities for thesis work and practicals.