Publications

Martini MA., Bikbaev K., Pang Y., Lorent C., Wiemann C., Breuer N., Zebger I., Debeer S., Span I., Bjornsson R., Birrell JA., Rodriguez-Macia P.:
Binding of exogenous cyanide reveals new active-site states in [FeFe] hydrogenases
In: Chemical Science (2023)
DOI: 10.1039/d2sc06098a

Van V., Brown JB., O’Shea CR., Rosenbach H., Mohamed I., Ejimogu N-E., Bui TS., Szalai VA., Chacón KN., Span I., Zhang F., Smith AT.:
Iron-sulfur clusters are involved in post-translational arginylation
In: Nature Communications (2023)
DOI: 10.1038/s41467-023-36158-z

Jansing M., Mielenbrink S., Rosenbach H., Metzger S., Span I.:
Maturation strategy influences expression levels and cofactor occupancy in Fe-S proteins
In: Journal of Biological Inorganic Chemistry (2022)
ISSN: 0949-8257
DOI: 10.1007/s00775-022-01972-1

Jan Borggräfe, Julian Victor, Hannah Rosenbach, Aldino Viegas, Christoph G. W. Gertzen, Christine Wuebben, Helena Kovacs, Mohanraj Gopalswamy, Detlev Riesner, Gerhard Steger, Olav Schiemann, Holger Gohlke, Ingrid Span & Manuel Etzkorn.:
Time-resolved structural analysis of an RNA-cleaving DNA catalyst
In: Journal of Nature (2021)
DOI: 10.1038/s41586-021-04225-4
Hannah Rosenbach, Eva Walla, George E Cutsail, James A Birrell, Marina Pascual-Ortiz, Serena DeBeer, Ursula Fleig, Ingrid Span:
The Asp1 pyrophosphatase from S. pombe hosts a [2Fe‑2S]2+ cluster in vivo
In: Journal of Biological Inorganic Chemistry (2020)
DOI: 10.1007/s00775-020-01840-w

Dr. Patricia Rodríguez-Maciá, Dr. Lisa M. Galle, Dr. Ragnar Bjornsson, Christian Lorent, Dr. Ingo Zebger, Dr. Yoshitaka Yoda, Prof. Dr. Stephen P. Cramer, Prof. Dr. Serena DeBeer, Prof. Dr. Ingrid Span, Dr. James A. Birrell:
Caught in the Hinact: Crystal Structure and Spectroscopy Reveal a Sulfur Bound to the Active Site of an O2-stable State of [FeFe] Hydrogenase
In: Journal of the German Chemical Society (2020)
DOI: 10.1002/anie.202005208
Hannah Rosenbach, Julian Victor, Jan Borggräfe, Ralf Biehl, Gerhard Steger, Manuel Etzkorn, Ingrid Span:
Expanding crystallization tools for nucleic acid complexes using U1A protein variants
In: Journal of Structural Biology (2020)
DOI: 10.1016/j.jsb.2020.107480
Hannah Rosenbach, Jan Borggräfe, Julian Victor, Christine Wuebben, Olav Schiemann, Wolfgang Hoyer, Gerhard Steger, Manuel Etzkorn and Ingrid Span:
Influence of monovalent metal ions on metal binding and catalytic activity of the 10–23 DNAzyme
In: Journal of Biological Chemistry (2020)
DOI: 10.1515/hsz-2020-0207
Hannah Rosenbach, Julian Victor, Manuel Etzkorn, Gerhard Steger, Detlev Riesner and Ingrid Span:
Molecular Features and Metal Ions That Influence 10-23 DNAzyme Activity
In: Journal of Molecules (2020)
DOI: 10.3390/molecules25133100

Marina Pascual-Ortiz, Adolfo Saiardi, Eva Walla, Visnja Jakopec, Natascha A Künzel, Ingrid Span, Anand Vangala, Ursula Fleig:
Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe
In: Journal of Molecular and Cellular Biology (2018)
DOI: 10.1128/MCB.00047-18
Lisa M. Galle, George E. Cutsail III, Volker Nischwitz, Serena DeBeer and Ingrid Span:
Spectroscopic characterization of the Cosubstituted C-terminal domain of rubredoxin-2
In: Journal of Biological Chemistry (2018)
DOI: 10.1515/hsz-2018-0142

Ethan N. Trana, Judith M. Nocek, Jon Vander Woude, Ingrid Span, Stephen M. Smith, Amy C. Rosenzweig, and Brian M. Hoffman:
Charge-Disproportionation Symmetry Breaking Creates a Heterodimeric Myoglobin Complex with Enhanced Affinity and Rapid Intracomplex Electron Transfer
In: Journal of the American Chemical Society(2016)
DOI: 10.1021/jacs.6b07672

Stefan G. Kathman, Ingrid Span, Aaron T. Smith, Ziyang Xu, Jennifer Zhan, Amy C. Rosenzweig, and Alexander V. Statsyuk:
A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism
In: Journal of the American Chemical Society(2015)
DOI: 10.1021/jacs.5b06839

Ingrid Span, Ke Wang, Wolfgang Eisenreich, Adelbert Bacher, Yong Zhang, Eric Oldfield, and Michael Groll:
Insights into the Binding of Pyridines to the Iron−Sulfur Enzyme IspH
In: Journal of the American Chemical Society(2014)
DOI: 10.1021/ja501127j

Dr. Ingrid Span, Dr. Ke Wang, Dr. Weixue Wang, Prof. Dr. Johann Jauch, Priv.-Doz. Dr. Wolfgang Eisenreich, Prof. Dr. Adelbert Bacher, Prof. Dr. Eric Oldfield, Prof. Dr. Michael Groll:
Structures of Fluoro, Amino, and Thiol Inhibitors Bound to the [Fe4S4] Protein IspH
In: Journal of the German Chemical Society (2013)
DOI: 10.1002/anie.201208469

Ingrid Span, Ke Wang, Weixue Wang, Yonghui Zhang, Adelbert Bacher, Wolfgang Eisenreich, Kai Li, Charles Schulz, Eric Oldfield:
Discovery of acetylene hydratase activity of the iron–sulphur protein IspH
In: Journal of Nature Communication (2012)
DOI: 10.1038/ncomms2052
Weixue Wang, Ke Wang, Ingrid Span, Johann Jauch, Adelbert Bacher, Michael Groll, and Eric Oldfield:
Are Free Radicals Involved in IspH Catalysis? An EPR and Crystallographic Investigation
In: Journal of the American Chemical Society (2012)
DOI: 10.1021/ja303445z
Ingrid Span, Tobias Gräwert, Adelbert Bacher, Wolfgang Eisenreich, Michael Groll:
Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate’s Hydroxymethyl Group during Catalysis
In: Journal of Molecular Biology (2012)
DOI: 10.1016/j.jmb.2011.11.033

Tobias Gräwert, Ingrid Span, Wolfgang Eisenreich, Felix Rohdich, Jörg Eppinger, Adelbert Bacher, and Michael Groll:
Probing the reaction mechanism of IspH protein by x-ray structure analysis
In: Journal of National Academy of Sciences (2010)
DOI: 10.1073/pnas.0913045107
Tobias Grwert, Ingrid Span, Adelbert Bacher, and Michael Groll:
Reductive Dehydroxylation of Allyl Alcohols by IspH Protein
In: Journal of the German Chemical Society (2010)
DOI: 10.1002/anie.201000833

Tobias Grwert, Felix Rohdich, Ingrid Span, Adelbert Bacher, Wolfgang Eisenreich, Joerg Eppinger, and Michael Groll:
Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction
In: Journal of the German Chemical Society (2009)
DOI: 10.1002/anie.200900548